Cognition and gait show a distinct pattern of association in the general population

BACKGROUND With brain aging, cognition and gait deteriorate in several domains. However, the interrelationship between cognitive and gait domains remains unclear. We investigated the independent associations between cognitive and gait domains in a community-dwelling population. METHODS In the Rotterdam Study, 1232 participants underwent cognitive and gait assessment. Cognitive assessment included memory, information processing speed, fine motor speed, and executive function. Gait was summarized into seven independent domains: Rhythm, Variability, Phases, Pace, Tandem, Turning, and Base of Support. With multivariate linear regression, independent associations between cognitive and gait domains were investigated. RESULTS Information processing speed associated with Rhythm, fine motor speed with Tandem, and executive function with Pace. The effect sizes corresponded to a 5- to 10-year deterioration in gait. CONCLUSIONS Cognition and gait show a distinct pattern of association. These data accentuate the close, but complicated, relation between cognition and gait, and they may aid in unraveling the broader spectrum of the effects of brain aging.